For the Malmö Breast Tomosynthesis Screening Trial (MBTST), almost 15,000 women underwent screening with both two-view mammography and a single-view, low-compression version of digital breast tomosynthesis, which uses low-dose X-rays to capture multiple breast images.Tomosynthesis had a higher sensitivity, although slightly lower specificity, than mammography for detecting breast cancer. Yaffe, Ph D, from Sunnybrook Research Institute, Ontario Institute for Cancer Research, and the University of Toronto, Canada, said that this study "suggests that single-view tomosynthesis is more accurate for screening than digital mammography." He adds that tomosynthesis "could potentially also be associated with reductions in radiation dose, complexity, patient discomfort, and cost as compared with two-view digital breast tomosynthesis plus two-view digital mammography, which is used in some settings".If these findings are "supported by cost-effectiveness studies, one-view digital breast tomosynthesis warrants consideration as the preferred breast cancer screening method in the future," the researchers comment. Furthermore, "In this study, digital breast tomosynthesis detected more invasive cancers, more invasive lobular cancers, and fewer ductal carcinomas in situ than digital mammography." Yaffe believes that the results will therefore "go a long way towards motivating a change away from the use of digital mammography in national breast cancer screening and towards adoption of digital breast tomosynthesis." He notes, however, that technical differences as well as differences in image acquisition and processing between systems "might reduce the generalisability of the results." Taken together, this means that the "question of whether digital breast tomosynthesis detects more of the cancers which, if undetected, would result in death or increased morbidity remains unanswered." He suggests that some answers to these questions are likely to come from the ongoing Tomosynthesis Mammographic Imaging Screening Trial, sponsored by the Sunnybrook Health Sciences Center.
This is not least in part due to the overlapping of breast tissue when generating the images.
This can hide tumor tissue and thus lead to a false negative result, or healthy tissue can have the appearance of a tumor, creating a false positive result.
Your breast is positioned against the platform again, and the clear plastic plate is used to apply pressure. The 3D mammogram images can be analyzed as a whole or examined in small fractions for greater detail.
For breast cancer screening purposes, the machine also creates standard 2D mammogram images.
The 3D mammogram is becoming more common, but it isn't available at all medical facilities.
A 3D mammogram is used as a breast cancer screening test to look for breast cancer in people with no signs or symptoms of the disease.
A doctor who specializes in interpreting imaging tests (radiologist) examines the images to look for abnormalities that may be breast cancer.
If the radiologist sees anything unusual, he or she will use your standard mammogram and any older mammogram images that are available to determine whether additional testing is needed.
Studies show that combining 3D mammograms with standard mammograms reduces the need for additional imaging and slightly increases the number of cancers detected during screening.
But more study is needed to understand whether 3D mammograms may reduce the risk of dying of breast cancer more than a standard mammogram alone.