Frank Gennari Thesis

To learn more or modify/prevent the use of cookies, see our Cookie Policy and Privacy Policy.Proefschrift ter verkrijging van de graad van doctor aan de Radboud Universiteit Nijmegen op gezag van rector magnificus prof. Nevertheless, people have come to realize that this approach falls short when the difficult questions are raised, in particular how the human brain sustains cognition and consciousness.

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Undoubtedly, studying the units—be it neurons or brain areas—in isolation is indispensible for explaining brain processes in health and disease.

The buzz-word is connectome: the matrix of structural links and functional associations between the basic units of the central nervous system.

The technique, introduced in the 1980’s, is called diffusion weighted imaging (DWI; or diffusion MRI).

The name is conveniently derived from its working principle.

The brain cells’ microstructural constituents hinder diffusion of water molecules in the brain.

The attenuation in the magnitude of diffusion can be measured with DWI.Although all mechanisms reduce to the neuronal level, and ultimately the chemical and physical levels, the answers to questions asked on the phenomenological level might lose their explanatory power when given at the neuronal level, invoking the need for the mesoscopic (i.e. For one, the construction of the comprehen-sive microscopic human connectome is far from within reach of neuroscience’s current technical capabilities.Pooling neuronal popula-tions into functional units at the meso- or macroscopic scale, however, can make them accessible to whole-brain measurement and analysis methods—as well as to our imagination. It is the widespread, though incredibly specific, connectivity of neurons that allows your brain to be the literal nervous centre of your world. We admire the skilful construction of the fibres in each muscle; how much more then ought we to admire it in the brain, where each of these fibres, confined in a small space, functions without confusion and without disorder. Now, why can’t your circulatory system—we might assume—do any of the thinking? If the substance is everywhere of fibres, as, in fact, it appears to be in several places, you must admit that these fibres have been arranged with great skill, since all the diversity of our sensations and our movements depends upon this. We are assured that wherever in the body there are fibres, they everywhere adopt a certain arrangement among themselves, created more or less according to the functions for which they are intended.By continuing to use this site, you consent to the use of cookies.We use cookies to offer you a better experience, personalize content, tailor advertising, provide social media features, and better understand the use of our services. Connectionist accounts of brain function have extensively contributed to contemporary commonly held beliefs. Kortmann, volgens besluit van het college van decanen in het openbaar te verdedigen op maandag om uur precies door Michiel Kleinnijenhuis geboren op 19 augustus 1981 te Den Ham PROMOTOREN: Prof. On the other hand, just as specific interactions between individuals in human society can result in inspira-tional achievements, you can rest assured that you can achieve extraordinary things with this remarkable dynamic network of connec-tions 3.5 billion years of evolution has endowed you with.


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