Also included was a questionnaire, to be completed in advance,22 concerning abdominal symptoms within the preceding year and previously diagnosed gastrointestinal disorders.Repeated requests were made in cases of non-response.
The sample size was reduced to 4581 Danes because 226 people of foreign extraction were excluded.
Between November 1982 and February 1984 3608 people (78.8%) entered the study.
Age-standardized incidence rates of distal gastric cancer were calculated for Māori (the indigenous population of New Zealand, composing 15% of the population), Pacific peoples (immigrants and their descendants from the Pacific Islands, composing 7% of the population), and European/other peoples (i.e.
non-Māori, non-Pacific, and non-Asian individuals, composing 76% of the population).
Nevertheless, it is preferable that clinicians diagnose the infection immediately after the bacteria have colonised the gastric mucosa, as early diagnosis and treatment may lower the risk of peptic ulcer disease or gastric cancer later in life.21 The aim of this study was to assess the symptoms of serologically diagnosed acute and chronic In October 1982 an age and sex stratified sample consisting of 4807 men and women, born in 1922, 1932, 1942, and 1952 (age 30, 40, 50, and 60 years), residing in the western part of Copenhagen County, was drawn from the National Danish Civil Registration System, in which all people living in Denmark are registered by a unique 10-digit number.
The distribution of sex, age, occupation, and marital status in the sampling area was compared with national statistics to ensure sample validity.22 All sample members received a standard letter containing information about the project and were invited to a general health examination.One hundred and ten people had died and 85.4% of the eligible population (n=2987/3498) attended the follow up examination.There was a significant difference in response rate among men because of a low attendance rate among 65 year olds, and a high attendance rate among those aged 45.24 Furthermore, non-responders were more likely than responders to be current tobacco smokers and originate from poor social strata.25 Medical examination, symptom questionnaires, and ultrasound assessment of the gall bladder were repeated.26 The project was approved by the Regional Research Ethics Commitee of Copenhagen County.Details of these sensitivity analyses are provided in the electronic supplementary material, and the results were not substantially affected.was greatest in the Pacific population at 71% and 82% of the relative difference in distal gastric cancer rates in the two cohorts born in 1924–1940 and in 1941–1955 respectively compared with the European/other population.People with epigastric pain and increased levels of Ig M antibodies to infection rates are slightly higher in people with non-ulcer dyspepsia (NUD) than in asymptomatic people.6-10 Other groups have succeeded in linking specific gastrointestinal symptoms, such as postprandial bloating and belching, to the presence of infection poses other problems.Acute infection occurs primarily in childhood and is rarely seen in adults. Consequently, it has been difficult to attain a consistent clinical image of this condition.All serum samples drawn in 1982 were thawed for the first time and analysed in June 1993.Circulating Ig G antibodies against a low molecular weight (LMW) fraction of antigens were measured in duplicate by using an in-house indirect enzyme linked immunosorbent assay (ELISA).28 The Ig G serology assay had previously been validated in 151 adult Danes with dyspeptic symptoms.For men born in 1926–1940, there were 5.1 million person-years of follow-up and 1254 cases of gastric cancer during the study period.For men born in 1941–1955, there were 7.6 million person-years of follow-up and 442 cases.